Grup de treball d’Osteoporosi de la Societat Catalana de Reumatologia

Presentació
Junta
Activitats
Documentació
Producció científica
Galeria d’imatges

Presentació

OSCAT (Grup de Treball d’Osteoporosi de la Societat Catalana de Reumatologia) està format per un grup de reumatòlegs socis de l’SCR amb interès per la patologia metabòlica òssia.

Objectius del Grup de treball d’OSCAT

Els objectius principals del grup són la recerca i la formació en el camp de l’osteoporosi i altres malalties metabòliques òssies, afavorint els projectes multicèntrics i els cursos formatius, especialment dirigits a residents de Reumatologia.

El grup també té l’objectiu de facilitar les relacions entre centres i entre investigadors.

Junta coordinadora d’OsCat

Foto Dr. Enrique Casado - Societat Catalana de Reumatologia

Coordinador

Dr. Enrique Casado
Reumatòleg especialista en Metabolisme Ossi
Hospital Universitari Parc Taulí. Sabadell

Foto Dra. Mireia Barceló - Societat Catalana de Reumatologia

Secretària

Dra. Mireia Barceló
Adjunta del Servei de Reumatologia i Coordinadora Unitat de Metabolisme Ossi
Hospital Universitari Vall d’Hebron. Barcelona

Foto Dra. Silvia Martinez - Societat Catalana de Reumatologia

Tresorera

Dra. Silvia Martínez
Cap del Servei de Reumatologia
Hospital Universitari MútuaTerrassa. Terrassa

Foto Dra. Laia Gifre - Societat Catalana de Reumatologia

Vocal

Dra. Laia Gifre
Especialista del Servei de Reumatologia
Hospital Universitari Germans Trias i Pujol. Badalona

Vocal

Dra. Dolors Grados
Adjunta del Servei de Reumatologia
Consorci Sanitari de l’Anoia

Foto Dra. Helena Florez - Societat Catalana de Reumatologia

Vocal

Dra. Helena Florez
Reumatòloga, treballant en el Metabolisme Ossi i les fractures per fragilitat.
Hospital Clínic de Barcelona

Activitats

Documents

Eines de càlcul online

Enllaços

Producció científica del Grup

Abstract

At present, data comparing the quantification methods for measurement of free vitamin D (direct assay [direct 25-OHD_F] and estimated by calculation [calculated 25-OHD_F]), are scarce. The aim of this study was to analyse the concordance between these two methods of 25-OHD_F analysis (direct vs. calculated).

METHODS:

Serum values of total 25-OHD (25-OHD_T), vitamin D binding protein (DBP) (by R&D Systems ELISA), calculated 25-OHD_F (by DBP, albumin and 25-OHD_T) and direct 25-OHD_F (by DIAsource ELISA) were analysed in 173 healthy women (aged 35-45years). Assessment of concordance was evaluated by the Bland-Altman plot and the total deviation index (TDI).

RESULTS:

The mean values of calculated and direct 25-OHD_F in these subjects were 5.27±2.5 and 3.83±1.01pg/mL, respectively. We found significantly lower values of 25-OHD_F on comparing subjects with and without vitamin D deficiency, independently of the method used. The total deviation index evaluated by the Bland-Altman plot showed low concordance for both measurements. Only low 25-OHD_F levels were concordant.

CONCLUSIONS:

This study shows that the concordance between these two methods of 25-OHD_F analysis is low and has a concentration dependent bias. Further studies are necessary to clarify the reference values and the indications for 25-OHD_F measurement.

PMID:29056531 DOI:10.1016/j.cca.2017.10.016

Vés a l’article online

Abstract

Determination of different forms of 25-OHD (total, free and bioavailable) in healthy young women does not offer additional advantages over standard 25-OHD_T for evaluating vitamin D deficiency. In these subjects 25-OHD_T values <15 ng/ml would be more appropriate for defining this deficiency.

INTRODUCTION:

Determination of 25-OH vitamin D serum levels (25-OHD) constitutes the method of choice for evaluating vitamin D deficiency. However, vitamin D-binding protein (DBP) may modulate its bioavailability thereby affecting correct evaluation of 25-OHD status. We analysed the impact of the determination of 25-OHD (total, free and bioavailable) on the evaluation its biologic activity (estimated by serum PTH determination) in healthy young women.

METHODS:

173 premenopausal women (aged 35-45 yrs.) were included. We analysed serum values of total 25-OHD (25-OHD_T), DBP, albumin, PTH and bone formation (PINP,OC) and resorption (NTx,CTx) markers. Free(25-OHD_F) and bioavailable (25-OHD_B) serum 25-OHD levels were estimated by DBP and albumin determinations and also directly by ELISA (25-OHD_F-2). We analysed threshold PTH values for the different forms of 25-OHD and the correlations and differences according to 25-OHD_T levels <20 ng/ml.

RESULTS:

62% of subjects had 25-OHD values <20 ng/ml and also had significantly lower 25-OHD_F and 25-OHD_B values, with no significant differences in bone markers and PTH values. The PTH threshold value was similar for all forms of 25-OHD (∼70 pg/ml). Women with PTH values >70 had lower 25-OHD_T (15.4 ± 1.4 vs. 18.3 ± 2.7, p < 0.05) and 25OHD_B values (1.7 ± 0.2 vs. 2.2 ± 0.09, p < 0.05). The different forms of 25OHD were significantly intercorrelated, with marginal correlations between PTH and 25-OHD_T (r = -0.136, p = 0.082).

CONCLUSIONS:

Determination of different forms of 25-OHD in healthy young women does not offer additional advantages over standard 25-OHD_T for evaluating vitamin D deficiency. In these subjects 25-OHD_T values <15 ng/ml would be more appropriate for defining this deficiency.

PMID:28466136 DOI:10.1007/s00198-017-4062-8

Vés a l’article online

Abstract

BACKGROUND:

The aims of this study were to establish robust reference intervals and to investigate the factors influencing bone turnover markers (BTMs) in healthy premenopausal Spanish women.

METHODS:

A total of 184 women (35-45 years) from 13 centers in Catalonia were analyzed. Blood and second void urine samples were collected between 8 a.m. and 10 a.m. after an overnight fast. Serum procollagen type I amino-terminal propeptide (PINP) and serum cross-linked C-terminal telopeptide of type I collagen (CTX-I) were measured by two automated assays (Roche and IDS), bone alkaline phosphatase (bone ALP) by ELISA, osteocalcin (OC) by IRMA and urinary NTX-I by ELISA. PTH and 25-hydroxyvitamin D (25OHD) levels were measured. All participants completed a questionnaire on lifestyle factors.

RESULTS:

Reference intervals were: PINP: 22.7-63.1 and 21.8-65.5 μg/L, bone ALP: 6.0-13.6 μg/L, OC: 8.0-23.0 μg/L, CTX-I: 137-484 and 109-544 ng/L and NTX-I: 19.6-68.9 nM/mM. Oral contraceptive pills (OCPs) influenced PINP (p=0.007), and low body mass index (BMI) was associated with higher BTMs except for bone ALP. Women under 40 had higher median values of most BTMs. CTX-I was influenced by calcium intake (p=0.010) and PTH (p=0.007). 25OHD levels did not influence BTMs. Concordance between the two automated assays for PINP and particularly CTX-I was poor.

CONCLUSIONS:

Robust reference intervals for BTMs in a Southern European country are provided. The effects of OCPs and BMI on their levels are significant, whilst serum 25OHD levels did not influence BTMs. Age, calcium intake, BMI and PTH influenced CTX-I. The two automated assays for measuring PINP and CTX-I are not interchangeable.

PMID: 26088062 DOI:10.1515/cclm-2015-0162

Vés a l’article online